ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life-changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 120 enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer® RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cell’s own editing machinery. Axiomer® RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.

Our Chemistry, Manufacturing and Control (CMC) Department is currently looking for a Scientist (Full-time) with a passion for chemistry to join our team in Leiden. The CMC department has a central role within the ProQR Therapeutics organization and is responsible for developing, manufacturing, and characterizing oligonucleotides and therapeutic formulations for research and clinical development.

The Role

The scientist will support the in-house laboratory activities of the Chemistry & Drug Substance Manufacturing team, which is part of the CMC department.

The successful candidate is enthusiastic about bench work and will work closely with other researchers/scientists in an interdisciplinary team environment to progress activities related to the production of oligonucleotides which includes:

  • Execution and supervision of the upstream and downstream oligo manufacturing
  • Processing and interpretation of analytical data
  • Accountable for the planning of activities and delivery to meet project milestones
  • Preparation, or revision, of standard operating procedures (SOPs)
  • Identification and implementation of continuous improvement opportunities
  • Authoring technical protocols and reports
  • Preparation, or revision, of standard operating procedures (SOPs)

Required qualifications:

  • Ph.D. in organic chemistry or related discipline with 2+ years of industry experience, or Master’s with 3-5 years of experience, or a Bachelor’s degree with 7+ years of pharmaceutical industry experience.
  • Good knowledge of peptide/oligonucleotide chemistry, process development, and manufacturing processes.
  • Strong laboratory skills and a high degree of attention to detail
  • Proficient in spoken and written English
  • Responsible with a proactive attitude who can work independently
  • Being flexible, analytical, and well-organized
  • A team player


  • Experience with oligonucleotide production is a plus
  • Automation experience to streamline repetitive tasks is a plus
  • Industrial experience in manufacturing
  • Knowledge of GMP and/or good laboratory practices (GLP)
  • Experience with GE/Cytiva Unicorn software is desired, but not required
  • Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is the freedom to act

ProQR as an employer

As an employer, we are a true believer in the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and professionally. We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome things.

We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage, or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

  • A competitive salary
  • 8% holiday allowance
  • 30 vacation days
  • An annual performance bonus
  • Stock options
  • A premium-free pension plan
  • A commuting allowance
  • A subsidized staff restaurant
  • Flexible working arrangements
  • Employee events (boot camp, Hipster café, and other social events)

Do you want to be part of our devoted team of enthusiastic professionals? Do you think you can contribute to achieving our mission? Do you want to work in a challenging environment where your work can really make a difference? If so, we’re looking forward to receiving your application by filling out our application form.

You can contact Silvia Catellani via if you have any questions.

Please note that screening is part of our selection procedure.

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