(Associate) Researcher, Oligonucleotide Chemistry

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ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life-changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 130 enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer® RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cell’s own editing machinery. Axiomer® RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.


Our Chemistry, Manufacturing and Control (CMC) Department is currently looking for an (Associate) Researcher, Oligonucleotide Chemistry (Full-time) to join our team in Leiden. We are looking for candidates with a passion for working in a chemical laboratory, this role would also suit a recent graduate with a background in chemistry or related disciplines. The CMC department has a central role within the ProQR Therapeutics organization. The CMC Department develops, manufactures, and characterizes oligonucleotides and therapeutic formulations for research, clinical development, and commercialization.

The Role

The Researcher will support the in-house lab activities of the Drug Substance & Chemistry team, which is part of the CMC department. The successful candidate will work closely with other researchers/scientists in an interdisciplinary team environment to help with all activities related to the production of oligonucleotides which includes:

  • Manufacturing of oligonucleotides by performing all stages of the process, such as the synthesis, cleavage&deprotection, and purification.
  • Perform proper documentation and accurate record-keeping of experimental data
  • Execution of analytical tests (HPLC, UV-Vis, and mass spectrometry)
  • Support preparation of technical protocols and reports
  • Support the preparation, or revision, of standard operating procedures (SOPs)
  • Support general lab activities such as equipment maintenance and inventory management

Required qualifications:

  • Bachelor’s degree in organic chemistry (HLO), analytical chemistry, biochemistry, biopharmaceutical sciences or related scientific discipline, or Master’s degree in the same fields.
  • Working experience minimum of 0-2 years (Associate researcher) or 2 to 5 years (Researcher).
  • Strong laboratory skills and a high degree of attention to detail.
  • Good understanding of, and hands-on experience with, analytical techniques such as HPLC, LCMS, and UV-Vis spectroscopy.
  • Proficient in spoken and written English.
  • A responsible person with a proactive attitude who can work independently.
  • Being flexible, analytical, and well-organized.
  • A team player.


  • Knowledge of oligonucleotide (or peptide) manufacturing (synthesis, purification and/or analysis) is a plus.
  • Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is the freedom to act.

This role would suit a recent graduate with a background in organic chemistry.

ProQR as an employer

As an employer, we are a true believer in the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and professionally. We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome things.

We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage, or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

  • 8% holiday allowance
  • 30 vacation days
  • An annual performance bonus
  • Stock options
  • A premium-free pension plan
  • A commuting allowance
  • A subsidized staff restaurant
  • Flexible working arrangements
  • Unlimited (un)healthy snacks and drinks
  • Employee events (boot camp, Hipster Café, and other social events)

Do you want to be part of our devoted team of enthusiastic professionals? Do you think you can contribute to achieving our mission? Do you want to work in a challenging environment where your work can really make a difference? If so, we’re looking forward to receiving your application by filling out our application form.

You can contact Silvia Catellani via recruitment@proqr.com if you have any questions.

Please note that a screening is part of our selection procedure.

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