… for directing site-specific A-to-I editing by endogenous ADAR enzymes Axiomer® platform applicability and potential in … that can direct site-specific deamination by endogenous ADARs (Adenosine Deaminases Acting on RNA). Rational EON …
This presentation reviews Axiomer editing oligonucleotides (EONs) structure activity, the potential of Axiomer platform as well as its applicability for the treatment of liver originated disorders.
… Successful Defense of a Key Axiomer® Patent Protecting ADAR-mediated RNA Editing LEIDEN, Netherlands & CAMBRIDGE, … which is related to targeted RNA editing using endogenous ADARs and is part of ProQR’s intellectual property estate …
… ProQR Appoints Peter A. Beal, PhD, as Chief ADAR Scientist LEIDEN, Netherlands & CAMBRIDGE, Mass., Dec. … of ProQR and a valued member of ProQR’s Scientific Advisory Board, where he has played an important role in shaping the Company’s ADAR-based RNA editing platform. Dr. Beal’s decades of …
… guide RNA can mimic the effect of hyperactive mutants and advance the approach of recruiting endogenous ADARs for site-directed RNA editing reported in Journal of … (E488 in human ADAR2), which flips the adenosine into the ADAR active site for deamination. Mutating this residue to …
… chemical modifications of EONs and the side-chains of the ADAR2 deaminase domain. Our data have been successfully … structure-based computational tools to other domains of ADARs and combine in silico screening with data from …
