Associate Researcher CMC

ProQR Therapeutics is a biotechnology company listed on NASDAQ with offices in Leiden, the Netherlands and Cambridge, Massachusetts, USA. ProQR is focused on the development of life changing RNA therapies to meet the unmet need of individuals and families with common and rare diseases. A team of 180+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is up to this challenge. We have the passion and commitment to make a difference in the lives of the communities we serve. Our proprietary Axiomer® RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer® RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), which is machinery present in all human cells to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases.

Our Chemistry, Manufacturing and Control (CMC) department is currently looking for an Associate Researcher (Full-time) to join our team.

We are looking for candidates with a passion for analytical and formulation work. This role would suit a recent graduate with a background in analytical chemistry or related disciplines. The CMC Department has a central role within ProQR developing, manufacturing, and characterizing oligonucleotides and therapeutic formulations for research, clinical development, and commercialization.

Location: Leiden, NL (on-site).

The Role:

The Associate Researcher will execute in-house lab activities in both the Drug Product team, which is part of the CMC department. The successful candidate will work closely with other researchers/scientists in an interdisciplinary team environment to help with all activities related to formulation, in support of oligonucleotide manufacturing:

• Prepare simple and complex formulations to provide the research material.

• Perform formulation characterization tests (such as pH, Osmolality, UV spectroscopy, viscosity, DLS).

• Perform proper documentation and accurate record-keeping of experimental data.

• Support preparation of technical protocols and reports.

• Support the preparation, or revision, of standard operating procedures (SOPs).

• Support general lab activities such as equipment maintenance and inventory management.

We expect our Associate Researcher to have/be:

• A Bachelor’s degree in analytical chemistry (HLO/ HBO), organic chemistry, biochemistry, biopharmaceutical sciences or related scientific discipline with 0-2 years of work experience, or 3-5 years of work experience and highly competent performance at a Laboratory associate level (MBO).

• Strong laboratory skills and a high degree of attention to detail.

• A good understanding of formulations, and hands-on experience in preparation of material for in vitro and in vivo experiments.

• A good understanding of, and hands-on experience with, analytical techniques such as pH, bacterial endotoxin, osmolality, DLS and UV-Vis spectroscopy.

• Proficiency in spoken and written English.

• A responsible person with a proactive attitude who can work independently.

• Flexible, analytical, and well-organized.

• A team player.

Preferred:

- Experience with GMP/ GLP.

- Someone who enjoys challenging situations and has the flexibility to work in a dynamic and fast-moving environment where there is the freedom to act.

ProQR as an employer

As an employer, we are a true believer of the value of a workforce in which people from diverse backgrounds are encouraged to develop themselves, personally and professionally. We believe that happy and energized people, working well together in an environment in which they thrive, will do phenomenal and awesome things.

We are committed to ensure that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and the contributions in all forms are recognized and valued.

We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• 8% holiday allowance

• 30 vacation days

• An annual performance bonus

• Stock options

• A premium-free pension plan

• A commuting allowance

• A subsidized staff restaurant

• Unlimited (un)healthy snacks and drinks

• Employee events (boot camp, Rebel Café and other social events)

Do you think you can contribute to achieving our mission? If so, we’re looking forward to receiving your application by filling out our application form.

You can contact Thomas Ardern-Mulhern via recruitment@proqr.com if you have any questions.

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