(Associate) Researcher Bioanalysis

ProQR Therapeutics is a NASDAQ-listed biotechnology company headquartered in Leiden, the Netherlands with an office in and Cambridge, Massachusetts, USA. At ProQR, we are on a mission to edit RNA, treat disease and change lives. A team of 180+ enthusiastic ProQRians from all walks of life and more than 30 different nationalities is committed to pioneering transformative RNA therapies to make a difference in the lives of the communities we serve.

Our proprietary Axiomer™ RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA), a protein which is present in all human cells, to repair G-to-A mutations, modulate protein, and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases. By harnessing the power of RNA editing, we aim to create a world where genetics inform your health - but never limit it.

ProQR is expanding its internal bioanalytical capabilities and is looking for an (Associate) Researcher with bioanalytical experience to join the Translational Development Team. The Translational Development Team works in a highly collaborative fashion and is responsible for animal pharmacology studies, PK and safety studies, bioanalysis, and generating the nonclinical packages required to support the clinical development of ProQR’s Axiomer® candidates.

Location: Leiden, NL (Onsite)

The role:

As (Associate) Researcher/Technician, you will assist and contribute to all non-GLP in-house bioanalytical activities to generate data on oligonucleotide concentrations in relevant matrices. Working closely with the Bioanalytical lab manager, the candidate will develop and qualify new methods, optimize sample preparation protocols and generate study data. We are looking for someone who can independently and quickly move from planning to experimentation, and report results promptly and accurately. Where appropriate, the candidate may contribute to other assays relevant for the Preclinical Team deliverables.

We expect our Researcher:

• To have HLO / Bachelor’s degree in (Bio)Pharmaceutical Sciences, Biology, Biochemistry, Biomedical Sciences, Analytical Chemistry or related field, with up to 3 years of relevant work experience.

• To develop and optimize bioanalytical methods (primarily HPLC and ELISA)

• To analyze, interpret and report data, according to applicable guidelines and SOPs

• To maintain and troubleshoot HPLC systems

• To be solution and result driven

• To plan and execute experiments

• To take care of laboratory organization and related administrative tasks

Personal skills and competencies that can make the difference:

• Hands-on experience with HPLC

• Experience with ELISA or MSD analysis and method development

• Experience with analysis of Oligonucleotide drugs (ONDs)

• Analytical mindset and problem solving attitude

• Accurate and quality aware

• Team player

• Flexible attitude, being able to work on multiple projects at the same time

• Autonomous and coachable

• Good communication skills

• Good knowledge of English both in word and writing

• A nice person 😊

Do you want to be part of our devoted team of enthusiastic professionals? Do you think you can contribute to achieving our mission? Do you want to work in a challenging & dynamic biotech environment where your work can really make a difference? If so, we’re looking forward to receiving your application by filling out our application form.

ProQR as an employer

As an employer, we value a diverse workforce in which people are encouraged to develop themselves both personally and professionally. We believe that when people are happy, energized and supported by an environment in which they can thrive, they can achieve extraordinary things. We are committed to ensuring that no employee, candidate, or job applicant receives less favorable treatment on the grounds of race, age, disability, pregnancy, religion, gender identity and expression, sexual orientation, marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued. We offer an exciting and innovative working environment in a very committed organization, with the following benefits:

• 8% holiday allowance

• 30 vacation days

• An annual performance bonus

• Stock options

• A premium-free pension plan

• A commuting allowance

• A subsidized staff restaurant

• Unlimited (un)healthy snacks and drinks

• Employee events (boot camp, Coffee and Collaboration Café and other social events)

We are looking for people who are inspired by our mission to edit RNA, treat disease and change lives. Are you up for the challenge? Submit your application via the Apply button below.

Please contact Silvia Catellani via recruitment@proqr.com if you have any questions.

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